Gloved hands preparing the Rigeneracons device in a clinic

The evidence, in plain English

What the research reports about pain, movement and recovery.

Every study behind Mytocel MSK® is listed here in plain English. Published knee studies report improvements in pain, movement and everyday function after treatment with cartilage micrografts. Follow-up includes a three-year study, in which the improvement in pain and knee scores was reported to be maintained, and studies tracking recovery over twelve months.

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Clinical findings

Pain relief and better knee function, followed over time.

Researchers recorded pain scores, everyday activities and knee function before and after treatment. The studies below show the reported changes, how many people took part and how long they were followed.

3 years¹

Follow-up in the knee chondropathy study

5.5 → 1.8¹

Average pain score out of 10 at six months, in 8 patients

12 months³

Pain and function followed in the 10-patient pilot

The studies

What happened to the people in the studies.

Peer-reviewed clinical

Marcarelli 2021, three-year knee series

Prospective uncontrolled case series · 8 patients · Follow-up: Six months and three years · OKS, VAS, MRI cartilage thickness

In a three-year study of eight people, pain scores fell from about 5.5 to about 1.8 out of 10 within six months, and the benefit was reported to last three years.¹

Disclosure: Three authors are employees of the technology developer.

View source

Peer-reviewed clinical

Tsoukas 2023, prospective knee osteoarthritis study

Prospective open-label observational study · 10 patients · Follow-up: Twelve months · KOOS (five subscales)

In a ten-person study, people reported less pain and better function at one and six months.²

Disclosure: Medical writing funded by the manufacturer; kits supplied.

View source

Peer-reviewed clinical

Helito 2024, twelve-month pilot study

Pilot prospective observational study · 10 patients · Follow-up: Twelve months · VAS, KOOS, WOMAC

Another ten-person study followed people for a year and reported improvements in pain and function.³

Disclosure: No external funding declared.

View source

In an early study of nine people with cartilage damage in the knee, eight reported less pain and better function.⁴

Scans

What the scans showed.

Scans in three of those patients showed thicker cartilage in two of them and thinner cartilage in one. The scans shown here are from one of the two people whose cartilage measured thicker.¹

Knee MRI, side view, before treatment — Side view, before

Knee MRI, side view, three years after treatment — Side view, three years

Knee MRI, front view, before treatment — Front view, before

Knee MRI, front view, three years after treatment — Front view, three years

Side effects

Side effects, as reported in the studies.

Because it is your own tissue there is no donor material and no rejection. In the published studies, covering 37 people, no serious side effects were reported, though every injection carries some risk.⁴¹²³

Your next step

Discuss the findings in relation to your knee.

Your symptoms, scans and activity goals help your clinician plan treatment and follow-up. Bring the studies to your consultation to discuss the outcomes that matter most to you.

Your clinician decides

Whether it suits you is decided by the clinician who examines you and looks at your scans. Actomed does not assess patients.

Studies mentioned on this page

1.Marcarelli M, Zappia M, Rissolio L, et al. Cartilage micrografts as a novel non-invasive and non-arthroscopic autograft procedure for knee chondropathy: three-year follow-up. J Clin Med. 2021;10(2):322. View source
2.Tsoukas D, Muntean I, Simos C, Sabido-Vera R. Prospective observational study of a non-arthroscopic autologous cartilage micrografting technology for knee osteoarthritis. Bioengineering. 2023;10(11):1294. View source
3.Helito CP, Pessei V, Zaniboni C, Muntean I, et al. Efficacy of autologous micrografting technology in managing osteoarthritis pain: a pilot study. Bioengineering. 2024;11(11):1119. View source
4.Dorta Fernández A, Baroni Luengo A, et al. Biostimulation of knee cartilage using autologous micrografts. Rehabilitation Science. 2018;3(1). Reproduced in the Mytocel MSK scientific studies booklet, p. 43. View source
5.Remedi (Regenera Activa). Mytocel MSK professional protocol. Manufacturer document. View source
6.Remedi. Mytocel MSK frequently asked questions. Manufacturer document. View source

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Actomed supplies and trains UK clinics; it does not assess or treat patients. A clinic can arrange an assessment, and being seen is not a decision to have any particular treatment.

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